Probe sonication liposomes pdf

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Influence of probe-sonication process on drug entrapment efficiency of liposomes loaded with a hydrophobic drug Journal Article • DOI: 10.1080/00914037.2018.1434651 • Yongju He 1 , Liangyu Luo 2 , Shuquan Liang 1 , Mengqiu Long 1 +1 more Sonication involves the application of ultrasound usually at frequencies >20 kHz to the solution of liposomes. The shear forces generated break up the liposomes into tiny nanoparticles; in the case of liposomes, to nanosized particles that have important applications in drug delivery systems, particularly for pulmonary delivery. Emulsification by sonication was performed using a 24 KHz sonicator (Dr Hielscher series, Model UP 400S). This system consisted of a generator, a converter, and a horn tip. The generator converted the conventional alternating electrical current from 60 Hz to 24 KHz. The converter transformed this energy to mechanical vibrations. The heart of the Six-min probe sonication produced liposomes with 123 ± 12 nm of mean particle size and 0.182 ± 0.049 of PI, indicating that the smallest and homogeneous liposomes were formed. However, temperature of liposome dispersions after 3-and 6-min sonication by probe sonicator increased up to 56.5 and 60.5 °C, respectively. After sonication at 293 K, below the Tm of the lowest meltingcomponent(296K,DMPC),asimilar DSCcurve was observed (Fig. 1 b). By contrast, after sonication at 302 or 306 K, between the DMPCand DPPC Tm's and below or above the intermediate DMPC/DPPC Tm, two main transition temperatures wereobserved-296 Kand 314.5 K, corresponding to the DMPCand To develop a rapid point-of-use process for the production of liposome-solubilised drug, initially the sonication process was optimised ().Using 15 sonication cycles of 90 ss/cycle produced liposomes 100-120 nm in size with PDI of 0.2 and a single particle size population were prepared (Fig. 2A and B).The effect of lipid concentration on particle size reduction was also investigated (Fig. 2C). • Liposomes are cocentric bilayerd vesicles in which aquoues volume is entirely enclosed by a membraneous lipid bilayer. • 1960 by Bangham et.al. • Targeting and delivery system • Natural and synthetic phospholipids • diameter ranges from 80nm to 100um f Introduction Slide Title Advantages • Provides selective passive targeting The effects of the homogenization mode, ratio of lecithin to cholesterol, extract concentration of Clitoria ternatea petals, and extraction temperature on the diameter and uniform of liposome were also investigated to protect their active biological activities. Furthermore, the objective of this study was to improve the homogeneous size distribution of liposomes by probe-type ultrasonication View Lab Report - liposomes classification prep and function.pdf from CHEMISTRY Organic ch at IIT Kanpur. Akbarzadeh et al. Nanoscale Research Letters 2013, PDF - The aim of the present study was to develop an optimized niosome formulation for the encapsulation of a poorly water-soluble drug by the ecological probe sonication method. Pluronic L121 and Span 60 were used as surface active agents and the optimization of the com